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Cortical functional abnormality and therapeutic strategies in patients with chronic dizziness Hiroshi Oe 1 , Hiroaki Naritomi 1 1Department of Cerebrovascular Medicine, National Cardiovascular Center Keyword: 慢性めまい症 , 脳磁図 , 聴覚誘発磁界反応 , 抗けいれん薬 pp.273-281
Published Date 2005/4/10
DOI https://doi.org/10.11477/mf.1431100045
  • Abstract
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Many old subjects suffer from chronic dizziness or floating sensation in spite of no abnormality in limb motor function or coordination. They often fall down or are scared of walking and may fall into a bedridden state after a long period. Unfortunately, none of clinical tests currently available can detect abnormality in the brain or vestibular system, and hence mechanisms of this chronic dizziness have yet remained unclear. The vestibular function, which is essential for maintaining the postural balance, is represented by auditory-vestibular special networks which are made of four different areas of the temporal and parietal cortices connected from the primary auditory center in the temporal cortex. Here, we show that measurements of auditory evoked magnetic fields(AEFs) in the parieto-temporal areas can detect functional abnormality of auditory-vestibular special networks specifically in patients with chronic dizziness. Electrical currents in the parieto-temporal areas were evoked by auditory stimulation, and their directions were demonstrated on a current-arrow map. In healthy subjects, the current-arrows always headed toward one direction in both sides of parieto-temporal areas. In patients with chronic dizziness, the current-arrows always showed a clockwise or counter-clockwise spinning pattern unilaterally or bilaterally. This abnormal pattern disappeared in patients whose dizzy sensation ameliorated following anticonvulsants. The detection of specific spinning pattern in AEFs is useful for evaluating electric hyperexcitability of the cortical auditory-vestibular special networks in patients with chronic dizziness of unknown cause and for elucidating the mechanisms of this dysequilibrium syndrome.


Copyright © 2005, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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