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ブロードマン領野12野は,11野とともに,前頭眼窩野に属する。前頭側頭葉変性症の味覚障害は,12/47野(両側)と関連するというVBM(voxel-based morphometry)データがある。またわれわれの検討では,パーキンソン病の意思決定機能障害とVBMでの萎縮部位(両側)が相関し,社会的認知機能とも関連することが明らかであった。さらに,時間順序の認識など時間認知機能との関連が指摘でき,この後さらに研究が進む可能性がある。
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Abstract
Broadman area 12, together with area 11, is located in the orbitofrontal area. A voxel-based morphometric (VBM) study revealed the association between bilateral brodmann areas 12/47 and taste disturbance in individuals with frontotemporal lobar degeneration (FTLD). In our VBM study in patients with Parkinson's disease, decision-making impairments were associated with atrophy of the bilateral Brodmann area 12, indicating that this area may play an important role in social cognitive function. Our recent study also demonstrated that this area may serve as time order judgement or mental time travel.
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