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Early Detection of Manganese Intoxication Based on Occupational History and T1-weighted MRI Toshio Fukutake 1 , Hajime Yano 1 , Ryutaro Kushida 2 , Yoshihide Sunada 2 1Department of Neurology, Kameda Medical Center 2Department of Neurology, Kawasaki Medical School Keyword: マンガン , マンガン中毒 , 溶接工 , 淡蒼球 , キレート治療 , manganese , manganese intoxication , welder , globus pallidus , chelation pp.175-180
Published Date 2016/2/1
DOI https://doi.org/10.11477/mf.1416200369
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Abstract

Manganese regulates many enzymes and is essential for normal cell function. Chronic manganese intoxication has an insidious and progressive course terminating to atypical parkinsonism with little therapeutic efficacy. For subjects with chronic manganese exposure such as welders, manganese intoxication can be detected early based on the presence of hyperintensity in the globus pallidus on T1-weighted MRI and abnormally high urinary excretion of manganese with a chelating agent even in cases of normal serum/urine level of manganese.

—(Received June 25, 2015; Accepted August 31, 2015; Published February 1, 2016)


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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