アンケート調査に基づいたパーキンソン病患者の骨折危険因子の検討

Risk Factors for Fractures in Parkinson's Disease: A Questionnaire Survey

はじめに

　パーキンソン病患者は骨折リスクが高く^1,2)，その予防は非常に重要である。パーキンソン病患者と骨粗鬆症，転倒の危険因子など骨折との間接的な関連についての検討は散見されるが^3-14)，骨折の直接の危険因子についてはあまり検討されていない^15-17)。本研究では骨折危険因子に関するアンケート調査を行い，特定疾患申請のために作成した臨床調査個人票の項目と併せてパーキンソン病患者の骨折の危険因子を検討した。

Abstract

　This study investigated the risk factors for fractures in patients with Parkinson's disease (PD). A questionnaire specifically designed to examine these risk factors was mailed to 172 PD patients registered in our self-developed PD database. We subsequently received replies from 158 patients, 22(14.8%)of whom had experienced fractures after PD onset. A multiple logistic regression model was used to evaluate the responses, and together with the clinical information stored in our PD database, it was revealed that psychiatric symptoms and falls within 1 year of our investigation were statistically correlated with the occurrence of fractures (adjusted odds ratio: 4.8 and 3.6, respectively). Thus, these results emphasize that psychiatric symptoms are an essential risk factor for fracture in PD patients. (Received: September 4, 2012, Accepted: January 28, 2013)