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Novel Electrophysiological Approaches to Clinical Epilepsy: Diagnosis and Treatment Kyoko Kanazawa 1 , Riki Matsumoto 1 , Masako Kinoshita 2 , Akio Ikeda 1 1Department of Neurology,Kyoto University 2Department of Neurology,National Hospital Organization Utano Hospital Keyword: epilepsy , DC , HFO , CCEP , EEG-fMRI pp.355-364
Published Date 2011/4/1
DOI https://doi.org/10.11477/mf.1416100879
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Abstract

 Seizure onset zone (SOZ) is currently defined by ictal epileptiform discharges, which are most commonly recorded as regional low-voltage fast waves or repetitive spikes. Interictal epileptiform discharges,on the other hand,are not specific enough for SOZ as they are recorded at zones other than the SOZ; they are also recorded from areas that do not generate the ictal pattern and from areas to which ictal discharges propagate. Besides spikes and sharp waves,a novel index of human epileptogenicity has been investigated in association with wide-band electroencephalography (EEG) analysis. We primarily noted the following during clinical neurophysiological analysis for clinical epilepsy. (1) Recent development of digital EEG technology enabled us to record wide-band EEG in a clinical setting. Thus,high frequency (>200 Hz) and low frequency (<1 Hz) components can be reliably recorded using subdural electrodes. Direct current shift,slow shift,ripple,and fast ripple can be well delineated,and they will be potentially useful in the diagnosis and management of epileptic patients. (2) Fiber tractography (morphological parameter) and cortico-cortical-evoked potentials with single cortical stimulation (electrophysiological parameter) elucidated cortico-cortical connections in human brain. The data thus obtained can help us understand the mechanism of seizure propagation and normal cortical functional connectivity. (3) Non-invasive simultaneous recording of EEG and functional magnetic resonance imaging (fMRI) provided information on the roles of deep brain structures associated with scalp-recorded epileptiform discharges. Interventional neurophysiology can shed light on the non-pharmacological treatment of epilepsy. In this report,we discuss these novel electrophysiological approaches to the diagnosis and treatment of clinical epilepsy.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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