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Clinical application and mechanisms of electric cortical stimulation in human epilepsy Masako Kinoshita 1 , Riki Matsumoto 1 , Nobuhiro Mikuni 2 , Akio Ikeda 1 1Department of Neurology, Graduate School of Medicine, Kyoto University 2Department of Neurosurgery, Graduate School of Medicine, Kyoto University Keyword: 皮質電気刺激 , 部分てんかん , 皮質機能マッピング , 発作抑制 pp.825-831
Published Date 2005/10/10
DOI https://doi.org/10.11477/mf.1431100099
  • Abstract
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Electric cortical stimulation is currently applied in the field of clinical epilepsy for cortical functional mapping during presurgical evaluation and for possible seizure control. Cortical electric stimulation to map cortical functions has been an established, gold-standard method since the Penfield's era, and recent studies showed that single pulse cortical stimulation could elicit cortico-cortical evoked potentials. It may help to understand the preexisting inter-cortical connectivity. Recent studies in animals and humans have demonstrated that both high- and low frequency electric cortical stimulation at seizure foci can suppress interictal spikes and seizures. Power spectrum analyses further demonstrated that high frequency stimulation can suppress background fast activities at the stimulated area in humans, that may suggest the inhibitory effects on the pyramidal neurons produced by cortical stimulation. Further information with regard to stimulating parameters to modify cortical excitability would promote clinical applications of electric cortical stimulation to control epileptic seizures in human epilepsy.


Copyright © 2005, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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