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Medical Management of Primary Central Nervous System Lymphoma Refractory or Resistant to Standard of Care Treatment Ryuya Yamanaka 1 1Research Center of Innovative Cancer Therapy,Kurume University School of Medicine Keyword: chemotherapy , primary central nervous system lymphoma , salvage therapy pp.1155-1164
Published Date 2009/10/1
DOI https://doi.org/10.11477/mf.1416100570
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Abstract

 Primary central nervous system lymphoma (PCNSL) is a non-Hodgkin's lymphoma arising in the central nervous system. Combined irradition and methotrexate-based chemotherapy is the standard of care treatment for PCNSL. The median overall survival achieved with this therapy is 25 to 51 months. Failure after first-line treatment has been reported in most patients with PCNSL. Salvage therapy is known to improve outcome, and although many different treatment modes have been attempted the optimal treatment schedule remains to be determined. This review analyses the efficacy of salvage therapy by focusing on data obtained from reports reporting on salvage therapy. Well-designed, randomized trials will help clarify issues such as the best chemotherapy regimen for second-line treatment. (Received: February 24,2009,Accepted: May 7,2009)


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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