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REM Sleep Behavior Disorder (RBD) in Dementia with Lewy Bodies (DLB)―A Study Using Short Sleep-disorder Questionnaire for DLB (SDQ-DLB) Kuniya Matsumura 1 , Chie Ichino 2 , Yuri Kudou 3,4 , Naoko Tachibana 5 , Toru Imamura 1,4 1Department of Speech Therapy,School of Health Sciences,Niigata University of Health and Welfare 2Division of Speech Therapy,Department of Rehabilitation,Niigata Rehabilitation Hospital 3Department of Rehabilitation,Midori Hospital 4Department of Neurology, Niigata Rehabilitation Hospital 5Department of Speech Therapy,School of Health Sciences,Niigata University of Health and Welfare Keyword: dementia with Lewy bodies , Alzheimer's disease , REM sleep behavior disorder , parasomnia , structured interview , clinical diagnosis pp.189-195
Published Date 2009/2/1
DOI https://doi.org/10.11477/mf.1416100432
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Abstract

 Objective: To assess the validity of the short sleep-disorder questionnaire for dementia with Lewy bodies (SDQ-DLB). SDQ-DLB is a newly developed structured interview containing 10 items for assessing REM sleep behavior disorder (RBD) in DLB. Subjects: The subjects were 23 patients with a clinical diagnosis of Alzheimer's disease (AD), 21 patients with possible DLB, and 7 patients with probable DLB. Methods: SDQ-DLB was administered to reliable informants representing each patient. The frequency of positive endorsement for each item was compared between the 3 patient groups. Results: The following 3 items of the questionnaire significantly differentiated between the patient groups: item 1 (Has the patient ever acted or talked in his/her nocturnal sleep while he/she seems to be half asleeps?), item 5 (Has the patient ever sat or got up on the bed (or the futon mattress) in his/her nocturnal sleep?) and item 6 (Has the patient ever gone out of the bed (or the futon mattress) to ambulate or to act violently in his/her nocturnal sleep while he/she seems to be half asleep?). The 7-point composite score of items 1 to 7 with 2 to 3 cut-off points showed 71% sensitivity in the patients with probable DLB, 51%sensitivity in the patients with possible DLB, and 91% specificity in the AD patients. Conclusion: The composite score of the 7 items of SDQ-DLB could distinguish AD from DLB with sufficient sensitivity and specificity. SDQ-DLB may be useful to evaluate RBD in DLB.

(Received: November 19,2007,Accepted: October 8,2008)


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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