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VITILIGO WITH ELEVATED INFLAMMATORY BORDER Toshihisa NOZAKI 1 , Norihisa YOKOTA 1 , Yoshiro OKADA 1 1Depatment of Dermatology, Nagoya University School of Medicine pp.996,1009-1017
Published Date 1969/10/1
DOI https://doi.org/10.11477/mf.1412200564
  • Abstract
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 Four cases of this disease were reported, of which only 5 cases had been reported in the world.

 They were all women who were 31 to 51 years of age. The lesions existed on the neck in 3 cases, and on the abdomen in 2 cases. They were solitary in 2 cases and multiple in one.

 The lesions were all incomplete depigmented macules surrounded with annular or irregularlyshaped, erythematosquamous, itchy, elevated inflammatory areas.

 Although it had been reported that some cases were accompanied with Sutton's leukoderma or bronchial asthma etc, cases in this study lacked these symptoms, but vitiligo vulgaris or a similar lesion accompanied in 2 cases respectively. In one case possibility of contact allergic mechanism by drug or underware was suggested.

 Histologic specimen from all cases showed acanthosis, intracellular edema of the epidermal cells and liquefaction degeneration of the basal cell layer.

 Three specimens revealed residual melanin granules in depigmented area.

 DOPA whole mount specimen proved decreased DOPA-tyrosinase activity around the boundary area of the macule.


Copyright © 1969, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1324 印刷版ISSN 0021-4973 医学書院

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