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Intratympanic Injection of Gentamicin to Treat Endolymphatic Hydrops Koji Yuen 1 1Department of Otolaryngology, Okayama University Medical School pp.481-485
Published Date 1997/6/20
DOI https://doi.org/10.11477/mf.1411901620
  • Abstract
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In some patients with Ménière's disease, verti-genous attacks can not be controlled by medicine, diuretics etc. For these patients aminoglycoside have been used therapeutically since 1940'. At first streptomycin was used to inhibit vestibular function. Recently, gentamicin has been used to control endolymph secretion. We administered intratympa-nic infusion of gentamicin in patients with endolym-phatic hydrops using two methods after Nedzelski and Magnusson, and the results of two methods were compared. Eight patients included seven with Ménière's disease and one with delayed endolym-phatic hydrops. Although vertigenous attacks disappeared in four cases with Nedzelski's method, hearing was improved in only one. In four cases with Magnusson's method, the attacks diminished and hearing was preserved. To decrease the possible risk of delayed ototoxicity and preserve hearing function, we recommend reduction of the dosage of gentamicin.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1316 印刷版ISSN 0914-3491 医学書院

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