網膜静脈閉塞症における血管攣縮因子の変動

Alterations in vasospastic factors in retinal vein occlusions

　網膜静脈閉塞症の発症と血管攣縮の因果関係について，内皮細胞依存性収縮因子（EDCF）の1つであるendotheline-1（ET-1）と拡張因子であるProstacyclineの代謝産物6-keto PGF_1αを測定し，次のような結果を得た。

　①ET-1はBRVO群およびCRVO群で対照群より高く，特にBRVO＋V．H．群では有意に高値を示した（P＜0.01）。

　②ET1はBRVO＋V．H．群および外傷，RD＋V．H．群で著明に上昇した。特に前者が後者に比較して有意に高値を示した（P＜0.05）。

　③6-keto PGF_1αは各群間に差を認めない。

　以上より，網膜静脈閉塞症のうち硝子体出血の発症に血管攣縮が関与している可能性を示唆した。

We quantitated plasma levels of substances related to vasospasm in 42 patients with retinal vein occlusions. The series included central retinal vein occlusion (CRVO) 12 cases and branch retinal vein occlusion (BRVO) 30 cases. BRVO was as-sociated with and without vitreous hemorrhage in 12 and 18 cases respectively.

We observed higher levels of endotheline-1 in CRVO and BRVO than in control. Endotheline-1 is considered to be a marker of endothelium-derived contracting factor (EDCF). Its value was particu-larly higher in cases of BRVO with vitreous hemor-rhage than in control (p＜0.01). It was also elevated in cases with vitreous hemorrhage secondary to trauma or retinal tear formation.

There were no significant changes in plasma levels of 6-ketoprostaglandin F_1α, which is thought to be a parameter of endothelium-derived retractir-g factor (EDRF).