加齢黄斑変性に対する放射線治療の効果に影響を与える因子についての検討

Factors related to the effect of radiation treatment for age-related macular degeneration

（R-7AM-4）　加齢黄斑変性31眼30例に対して1回2Gy，総計20Gyの放射線照射を行った。1年後の評価で，21眼（68％）でスコア化した病巣の眼底像と蛍光像が改善し，Log視力は2割で改善し，5割で維持された。視力改善率は治療前の滲出斑の量が多いほど有意に良かった（p＜0.01）。血管板の型（クラシック主体，オカルト主体，オカルトのみ），血管板の大きさ，網膜下液の量，網膜出血の有無は，視力改善率とは相関しなかった。

We treated 31 eyes of 30 patients with age-related macular degeneration by 10 sessions of radiation totalling 20 Gy. One year after treatment, 21 eyes (68%) showed improvement in the score of fundus lesions based on funduscopic and fluorescein angiographic findings. The visual acuity, expressed as LogMAR, improved in 20% and remained stationary in 50% of eyes. Improvement in visual acuity was significantly better in eyes with greater amount of exudate before treatment (p ＜0.01) . Posttreatment visual acuity was correlated neither with the amount of subretinal fluid, presence of retinal hemorrhage, the size of subfoveal vascular membrane, nor its type as classified into classic, mainly occult or occult type. Above findings show that radiation is more effective in eyes of age-related macular degeneration with massive exudate.