Systemic ganciclovir with vitrectomy was effective in two cases of acute retinal necrosis Hikaru Nakamura 1 , Seiichi Ishimoto 1 , Kimihiko Fujisawa 1 , Toyokazu Okada 1 , Yoshihisa Tahara 1 , Takehiko Nakamura 1 , Kazutaka Kimura 1 , Hajime Inomata 1 1Dept of Ophthalmol, Faculty of Med, Kyushu Univ pp.1599-1603
Published Date 1999/8/15
DOI https://doi.org/10.11477/mf.1410906499
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Two females, aged 45 and 72 years respectively, presented with unilateral acute retinal necrosis. Varicella zoster virus was detected in the anterior aqueous and vitreous. After systemic acyclovir proved futile, both cases were given ganciclovir followed by vitrectomy. Intravitreal perfusion of ganciclovir was also performed during surgery in one case. These treatments led to regression of retinal lesions. These cases illustrate that ganciclovir with vitrectomy may be effective for acute retinal necrosis resistant to acyclovir.

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