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Fisher症候群患者の急性期血清中にガングリオシドGQ1bに対するIgG抗体が特異的に認められ,同症候群の有用な診断法として応用できる。抗体価は眼球運動障害と相関している。本研究ではFisher症候群以外の外眼筋麻痺患者41例(原因確定例26例,不明15例)を対象として血清中の同抗体をELISA法で検索した。原因不明の外眼筋麻痺2例のみに同抗体が検出され,他の39例はすべて陰性であった。抗体陽性の2例はFisher症候群と同様の機序で眼筋麻痺が出現した非典型的Fisher症候群と考えられた。血清抗GQlb IgG抗体の検査は眼球運動障害を呈する患者の病態診断の上で有用と考えられる。
Patients with Fisher syndrome have been known to frequently possess serum antibody against GQ1b ganglioside in the acute phase. This antibody is regarded to be a marker for diagnosis. Further, this antibody has been shown to be associated with ophthalmoplegia. We evaluated 41 patients with ophthalmo-plegia regarding anti-GQ1b antibody using ELISA technique. The series comprised 26 patients with evident causes and 15 with unknown ones. Anti-GQ1b antibody was positive in 2 patients with unknown causes and negative in the other 39 patients. These 2 patients with positive anti-GQ1b antibody were diagnosed as atypical Fisher syndrome. It appeared that this antibody might induce ophthalmoplegia by the same pathogenetic mechanism as in typical Fisher syndrome.`
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