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Anti-GQ1b ganglioside antibody in ophthalmoplegia Tone Suzuki 1 , Atsuro Chiba 2 , Susumu Kusunoki 2 , Kazuo Misu 1 , Tsuneaki Fujita 1 , Yoshitaka Obara 1 1Dept of Ophthalmol, Dokkyo Univ Sch of Med, Koshigaya Hosp 2Dept of Neurol, Univ of Tokyo, Faculty of Med pp.497-500
Published Date 1995/3/15
DOI https://doi.org/10.11477/mf.1410904223
  • Abstract
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Patients with Fisher syndrome have been known to frequently possess serum antibody against GQ1b ganglioside in the acute phase. This antibody is regarded to be a marker for diagnosis. Further, this antibody has been shown to be associated with ophthalmoplegia. We evaluated 41 patients with ophthalmo-plegia regarding anti-GQ1b antibody using ELISA technique. The series comprised 26 patients with evident causes and 15 with unknown ones. Anti-GQ1b antibody was positive in 2 patients with unknown causes and negative in the other 39 patients. These 2 patients with positive anti-GQ1b antibody were diagnosed as atypical Fisher syndrome. It appeared that this antibody might induce ophthalmoplegia by the same pathogenetic mechanism as in typical Fisher syndrome.`


Copyright © 1995, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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