眼部帯状庖疹での血清抗水痘ウイルスIgG螢光抗体価測定の有用性

Value of IgG antibody titers to varicella zoster virus by fluorescent antibody technique in ophthalmic zoster

　眼部帯状炮疹（VZV）患者30例（60検体）につき，発症後1年以内の血清抗VZV-IgG（FA）抗体価を螢光抗体間接法により測定し診断における有用性を検討した。対照群46例（46検体）のIgG （FA）抗体価は全例40倍以下であった。眼部帯状庖疹患者のIgG （FA）抗体価は発症後1か月目まで上昇し，その後緩やかに低下した。発症後1年を通じて160倍以上の高値を示すものは50％みられた。血清補体結合（CF）抗体価とIgG （FA）抗体価は正の相関を示した。

　単一血清でも抗VZV-lgG （FA）抗体価が160倍以上であれば，水痘・帯状庖疹ウイルス感染症が疑われ，本法はCF抗体価測定と併用すべき有用な方法であると思われた。

We evaluated the serological antibodies in 30 patients with ophthalmic herpes zoster and in 46 normal controls. We paid particular attention of IgG antibodies to varicella-zoster virus (VZV) by fluorescent antibody technique and complement fixation titers.

Control subjects invariably showed low antibody titers of less than 1:4 by complement fixation and 1:40 by fluorescent antibody technique. In patients with herpes zoster, the titers of IgG antibodies to VZV by fluorescent antibody technique incrased during the 3rd and 4th week to gradually decrease thereafter. High titers of more than 1:80 were maintained for 9 months at least. The titers of IgG antibodies were positively correlated with those by complement fixation technique (r:75).

There seemed to be a high possibility of VZV infection if the titer of IgG antibodies to VZV by fluorescent antibody technique. This test appeared to be useful regardless of availability of paired sera.