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Rinsho Ganka Volume 39, Issue 3 （March 1985）

臨床眼科 39巻3号（1985年3月発行）

Japanese English

特集第38回日本臨床眼科学会講演集　（その2）

学会原著

人眼ERP（Early Receptor Potential）の臨床的研究—第16報二，三の眼疾患における単色閃光ERP所見 Studies on the early receptor potential in the human eye. XVI. Monochromatic flash ERP in some ocular diseases 玉井嗣彦 ¹ , 和田秀文 ¹ , 北川康介 ¹ , 割石三郎 ¹ , 上野脩幸 ¹ , 野田幸作 ¹ , 岸茂 ¹ , 豊田英治 ¹ , 伊与田加寿 ¹ , 竹村恵 ¹ , 佐々木徹 ¹ , 内田邦子 ¹ Akihiko Tamai ¹ , Hidefumi Wada ¹ , Kosuke Kitagawa ¹ , Saburo Wariishi ¹ , Hisayuki Ueno ¹ , Kosaku Nada ¹ , Shigeru Kishi ¹ , Eiji Toyota ¹ , Kazu Iyota ¹ , Megumi Takemura ¹ , Toru Sasaki ¹ , Kuniko Uchida ¹ ¹高知医科大学眼科学教室 ¹Dep. of Ophthalmol., Kochi Med. Sch. Kohasu pp.293-298

発行日 1985年3月15日 Published Date 1985/3/15

DOI https://doi.org/10.11477/mf.1410209360

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Abstract 文献概要
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（1）赤色盲（12歳，男性）の場合，緑色，青色閃光ERPには一正常者と比べて有意の振幅変化はみられなかったが，赤色閃光ERPにおいて明らかな振幅（R₁-R₂）の減弱がみられた．緑色盲（6歳，男性）の場合には，赤色，青色閃光ERPには有意の変化はみられなかったが，緑色閃光ERPにおいて明らかな振幅の減弱がみられた．

（2）錐体ジストロフィー（25歳，女性）の場合，赤色，緑色，青色の各閃光ERPにおいて，著しい振幅の減弱が観察された．

（3）網膜色素変性症（65歳，女性）の場合，ERGはnonrecordableであったが，いわゆる"dissociation phenomenon"として，赤色，緑色，青色の各閃光ERPは減弱を示すものの認められた．

（4）これより，視細胞外節レベルでの錐体機能障害の把握にこの種の単色閃光ERPは有用であると思われる．

The human monochromatic flash ERP (early receptor potential) was studied in patients with protanopia (12-year-old male), deuteranopia (6-year-old male), cone dystrophy (25-year-old female) and pigmentary retinal dystrophy (65-year-old female). Color filters used were : (1) a red Kodak Wratten filter No. 23A (transmission above 570 nm) for the red flash ERP ; (2) a green Wratten filter No. 57 (transmission from 460 to 620 nm with max-imum at 530 nm) for the green flash ERP; (3) a blue Wratten filter No. 47 (transmission from 380 to 520 nm with peak at 440 nm) for the blue flash ERP.The ERP amplitude was measured from the peak of the R₁ to the peak of the R₂.

A remarkable decrease in the amplitude of the red flash ERP was observed in the protanope, as compared with a normal control. No significant changes were obtained in either green or blue flash ERP amplitude.

A remarkable decrease in the amplitude of the green flash ERP was detected in the deuteranope, compared to normal. No significant changes were obtained in either red or blue flash ERP amplitude.

Markedly reduced ERP amplitudes were detected through the red, green and blue test flashes in the patient with cone dystrophy, as compared with a normal control. The ERG was nonrecordable in the patient with pigmentary retinal dystrophy. The red, green and blue flash ERPs were recordable as a "dissociation phenomenon", though their amplitudes were re-duced, compared to normal.

The findings thus indicate that the monochro matic flash ERP is of high clinical value in detec-ting functional deterioration of the cones at the level of the receptor outer segments.