Ocular manifestations mimicking Vogt-Koyanagi-Harada disease in a case of malignant lymphoma Yoriko Nakanishi 1 , Takayuki Nagai 1 , Hitomi Kondo 1 , Tomoko Nagai 1 , Hiroyuki Yamamoto 1 1Dept of Ophthalmol,Nippon Steel Hirohata Hosp pp.1169-1173
Published Date 2010/7/15
DOI https://doi.org/10.11477/mf.1410103268
  • Abstract
  • Look Inside
  • Reference

Abstract. Purpose:To report a case of malignant lymphoma who showed ocular symptoms mimicking Vogt-Koyanagi-Harada(VKH)disease. Case:A 57-year-old male was referred for impaired visual acuity in both eyes. He had been diagnosed with VKH disease 4 weeks before. Pulse therapy with systemic corticosteroid was futile. He had received surgery for brain tumor 16 months before. Findings:Corrected visual acuity was 0.06 right and 0.2 left. Fluorescein angiography showed leakage and pooling of dye through the retinal pigment epithelium. Optical coherence tomography showed serous detachment. The findings were compatible with the diagnosis of VKH disease. Subtenon injection of triamcinolone acetonide and systemic cyclosporine resulted in improved visual acuity and persistent intraocular inflammation. It then became apparent that the brain tumor was malignant lymphoma. He started to show signs suggestive of tumor necrosis and died 7 weeks after his initial visit. Conclusion:This case illustrates that malignant lymphoma may masquerade as VKH disease and that due attention is needed to this possibility.

Copyright © 2010, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院