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症例は51歳の男性であり,強直性脊椎炎に対し,22年あまり非ステロイド性抗炎症薬で加療され,両股関節の破壊を来していた.両人工股関節置換術後,歩容は著明に改善したが,術後も疾患活動性は高かった.低用量(3mg/kg)インフリキシマブ(INF)投与でCRPは陰性化したが,効果は不十分だった.INF5mg/kgに増量したことにより,BASDAI(Bath Ankylosing Spondylitis Disease Activity Index)は4.5から増量後12週で2.8と改善を認めた.
A 51-year-old man with a 22-year history of ankylosing spondylitis treated with NSAIDs alone developed destruction of both hip joints. Bilateral THA resulted in a marked improvement in the patient's gait, but his disease activity was high. Treatment with low-dose infliximab (3 mg/kg) resulted in conversion to CRP-negative, but its efficacy was insufficient. Dose escalation (5 mg/kg) improved the BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) from 4.5 to 2.8 in 12 weeks.
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