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Bilateral Total Hip Arthroplasty and Low-dose (3mg/kg) Infliximab in Ankylosing Spondylitis. Case Report Kenta KAMO 1 , Kazushi HARAGUCHI 2 1Department of Orthopaedics Surgery, JR Kyusyu Hospital 2Department of Orthopaedics Surgery, Saiseikai Yahata Hospital Keyword: 強直性脊椎炎 , ankylosing spondylitis , 人工股関節置換術 , total hip arthroplasty , 低用量インフリキシマブ , low-dose infliximab pp.879-883
Published Date 2011/9/25
DOI https://doi.org/10.11477/mf.1408102114
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 A 51-year-old man with a 22-year history of ankylosing spondylitis treated with NSAIDs alone developed destruction of both hip joints. Bilateral THA resulted in a marked improvement in the patient's gait, but his disease activity was high. Treatment with low-dose infliximab (3 mg/kg) resulted in conversion to CRP-negative, but its efficacy was insufficient. Dose escalation (5 mg/kg) improved the BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) from 4.5 to 2.8 in 12 weeks.


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電子版ISSN 1882-1286 印刷版ISSN 0557-0433 医学書院

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