骨外性骨肉腫に対する系統的治療の有用性の検討

Clinical Implications of Neoadjuvant Chemotherapy for Patients with Extraskeletal Osteosarcoma

　目的：骨外性骨肉腫は高齢者に好発する稀で予後不良な軟部肉腫である．しかし，neoadjuvant化学療法により予後が改善するという報告もある．骨外性骨肉腫の治療成績について検討した．

　方法：当グループで治療した骨外性骨肉腫17例について検討した．

　結果：系統的治療群(wide margin以上の手術＋術前and/or術後化学療法)の5年生存率は54.6%，非系統的治療群は16.7％であり，有意に予後の改善を認めた．

　まとめ：骨外性骨肉腫に対し系統的治療を行うことで予後の改善する可能性がある．

　Purpose：Extraskeletal osteosarcoma is a rare type of soft tissue sarcoma with a predilection for occurrence in the elderly, and it has a poor prognosis.　However, several recent studies have reported that neoadjuvant chemotherapy improved the prognosis.

　Methods：We retrospectively investigated the clinical outcome of 17 extraskeletal osteosarcoma patients treated by our group to clarify the clinical impact of neoadjuvant chemotherapy.

　Results：The 5-year overall survival rate of the multimodal treatment group (wide surgical margin ＋ chemotherapy before and/or after surgery) and the non-multimodal treatment group was 54.6% and 16.7%, respectively, indicating that multimodal treatment that included neoadjuvant chemotherapy improves the prognosis of patients with extraskeletal osteosarcoma.

　Conclusions：Neoadjuvant chemotherapy improve the prognosis of patients with extraskeletal osteosarcoma.