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Clinicopathological Study of Giant Cell Tumors of Small Bones Michiro Yanagisawa 1 , Kyoji Okada 2 , Takahiro Tajino 3 , Tomoaki Torigoe 4 , Akira Kawai 5 , Jun Nishida 6 , Hiroshi Kakizaki 7 , Tomomi Kusumi 8 , Tadashi Hasegawa 9 1Department of Orthopedic Surgery, Hirosaki University Graduate School of Medicine 2School of Health Sciences, Akita University 3Department of Orthopaedic Surgery, Fukushima Medical University 4Department of Orthopedic Surgery, Juntendo University 5Department of Orthopedic Surgery, National Cancer Center 6Department of Orthopedic Surgery, Iwate Medical University 7Department of Orthopedic Surgery, Hirosaki National Hospital 8Department of Pathology, Aomori Prefectural Central Hospital 9Department of Pathology, Sapporo Medical University Keyword: 骨巨細胞腫 , giant cell tumor of bone , 小骨 , small bone , 臨床病理学的検討 , clinicopathological study pp.367-371
Published Date 2010/4/25
DOI https://doi.org/10.11477/mf.1408101715
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 Clinicopathological features of 11 cases of giant cell tumors of small bones were investigated. Giant cell tumor in small bones were seen in younger patients compared to those in large bones, with about half arising in patients under 20 years old. Excessive expansion of the cortical bone was a special feature. There were 2 cases of recurrence and one case of lung metastasis.

 Giant cell tumor of small bones may have more aggressive behavior evidenced by 5 cases requiring en block resections or amputation as a primary surgery. The immunohistochemistry of p63 may be useful for differential diagnosis from giant cell reparative granuloma, in addition, the number of positive cells and there intensity may have value as a prognostic factor.


Copyright © 2010, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1286 印刷版ISSN 0557-0433 医学書院

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