Rinsho Seikei Geka Volume 43, Issue 12 (December 2008)

Effects of Blood Flow on Nerve Roots in Lumbar Spinal Stenosis Miho Sekiguchi 1 , Shin-ichi Konno 1 , Shin-ichi Kikuchi 1 1Department of Orthopaedic Surgery Fukushima Medical University School of Medicine Keyword: 馬尾(cauda equina) , 血流(blood flow) , 血管内皮細胞(endotherial cells) pp.1211-1218
Published Date 2008/12/25
DOI https://doi.org/10.11477/mf.1408101418
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 Neurophysiologic function and potential therapeutic agent were investigated using lumbar spinal stenosis models that were developed according to a clinical pathogenesis. Nerve conduction velocity(NCV) and blood flow in nerve root decreased after compression of nerve root or cauda equina. The pain threshold decreased after nerve root compression whereas not in the cauda equina compression. In addition,a dysfunction of endothelial cells was induced by compression of cauda equina and it might lead to reduce blood flow due to serotonin. Prostaglandins,5HT receptor antagonist,and cilostazole effect to improve blood flow in nerve root after cauda equian compression therefore they might be potential therapeutic agent for lumbar spinal stenosis.

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43巻12号 (2008年12月)
電子版ISSN 1882-1286 印刷版ISSN 0557-0433 医学書院