慢性多量飲酒者におけるP300検査と脳血流検査

Correlation between Event-related Potentials and Regional Cerebral Blood Flow in Chronic Alcoholism

　神経疾患の既往がなく，痴呆や精神症状のない慢性多量飲酒者11例においてP300検査およびキセノンCT脳血流検査を行い，P300潜時と局所脳血流量に相関があるかを検討した。慢性多量飲酒者では，P300潜時は有意に延長し，視床の血流量との間に有意な負の相関がみられた。慢性多量飲酒者では，明らかな臨床症状がなくても認知機能障害があり，視床の血流量低下と関係している可能性が示唆された。

We report a correlation between P300 and cere-bral blood flow in 11 patients with chronic moderate alcoholism, The patients had been drinking more than 83 ml pure alcohol equivalent everyday for more than 10 years and did not have any other neurological diseases. The P300 latency was significantly longer in the chronic alcoholism group than in the age-matched healthy control group. There was a significant negative correlation between the P300 latency and the thalamus blood flow in the chronic alcoholism group.