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High-dose Intravenous Immunoglobulin Treatment in Chronic Inflammatory Demyelinating Polyneuropathy Masahiko Tomiyama 1 , Masayuki Baba 2 , Muneo Matsunaga 2 , Hiroto Takada 1 , Toshimi Okushima 3 , Shohko Narita 3 , Kazuo Takebe 1 1Department of Medicine, Hirosaki University School of Medicine 2Department of Neurology, Hirosaki University School of Medicine 3Department of Neurology, Aomori Prefectural Central Hospital Keyword: human immunoglobulin , chronic inflammatory demyelinating polyneuropathy , nerve conduction study pp.979-982
Published Date 1992/11/1
DOI https://doi.org/10.11477/mf.1406900400
  • Abstract
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We treated two patients with chronic inflam-matory demyelinating polyneuropathy (CIDP) with high - dose intravenous immunoglobulin (HIG). The patients received 400mg/kg of immunoglo-bulin a day for five days. One patient, who had failed to respond to prednisolone before, was trea-ted with HIG, 18 months after the onset. His moter symptoms resolved immediately after the com-mencement of HIG. Electrophysiologically, thecompound muscle action potentials increased in amplitude in all nerves examined and F wave reappeared in the left median nerve. The electro-physiological changes were compatible with improvement of conduction blocks. This patient had headache and exanthema during the HIG ther-apy, but they settled after cessation of the infusion. The other patient was administered HIG as an initial treatment, four months after the onset. HIG was of no effect in this case, but he showed remark-able recovery during the following prednisolone therapy. Although corticosteroid therapy is the first choice for CIDP, there are CIDP patients who do not respond to steroid or can not complete the steroid therapy because of adverse effects. HIG is an expectative and recommendable treatment for the steroid-resistant CIDP patients.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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