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CHANGES IN EPIDURAL PULSE PRESSURE IN BRAIN EDEMA FOLLOWING EXPERIMENTAL FOCAL ISCHEMIA Mitsuhito Mase 1 1Department of Neurosurgery, Nagoya City University Medical School Keyword: intracranial pressure , pulse pressure , intracranial components , brain edema , focal ischemia pp.643-649
Published Date 1990/7/1
DOI https://doi.org/10.11477/mf.1406900074
  • Abstract
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It is well known that epidural pulse pressure (PP) increases with rising intracranial pressure (ICP). However, PP at the same ICP is not al-ways identical in various intracranial pathologies. Many authors have investigated PP at increased states of ICP, but few studies related to brain ede-ma have been done. This study was carried out in order to clarify the changes of PP in brain edema following focal ischemia. ICP and PP were mea-sured in two groups of anesthetized dogs ; 1) in-creased volume of CSF by cisternal saline injection (control, n=5), 2) brain edema caused by focal is-chemia (edema, n=11). Ischemia was induced by electro-coagulation of the right anterior cerebral artery and by clipping the right middle cerebral artery and right internal carotid artery transorbi-taly. The brain was recirculated for 6 hours after 2 hours of ischemia. The ischemic areas were id-entified by Evans blue, triphenyl tetrazolium chlo-ride (TTC) or histological examination. Water content of the brain was measured by the wet-dry weight method.

The canine focal ischemic model showed consi-stent ischemic damage in the caudate nucleus and produced brain edema successfully. PP increased linearly with rising ICP to 35 mmHg, and PP in the edema group was significantly smaller than that in the control group at the same ICP value. The slopes of the regression equation of ICP and PP were significantly different between the edema and control group (edema : 0.061 ± 0.030, control : 0.107±0.015, mean±SD, p< 0.01).

These results suggest that PP is easily affected by ischemic brain edema. Brain edema means in-crease of water content of brain tissue which is one of intracranial components. I would like to con-clude that PP is affected even at the same ICP value when intracranial components have altered.


Copyright © 1990, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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