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Brain and Nerve No to Shinkei Volume 42, Issue 4 （April 1990）

Brain and Nerve 脳と神経 42巻4号（1990年4月発行）

Japanese English

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実験的家兎粥状動脈硬化症における中枢神経組織・肝・腎のカルシウム，燐，アルミニウム—vinpocetineのエレメント低下作用について CONTENTS OF CALCIUM, PHOSPHORUS AND ALUMINUM IN CENTRAL NERVOUS SYSTEM, LIVER AND KIDNEY OF RABBITS WITH EXPERIMENTAL ATHEROSCLEROSIS:SCAVENGER EFFECTS OF VINPOCETINE ON THE DEPOSITION OF ELEMENTS 安井昌之 ¹ , 矢野一郎 ¹ , 大田喜一郎 ² , 大島章 ³ Masayuki Yasui ¹ , Ichiro Yano ¹ , Kiichiro Ota ² , Akira Oshima ³ ¹和歌山県立医科大学神経病研究部 ²和歌山県立医科大学検査診断学 ³和歌山県立医科大学第一病理 ¹Division of Neurological Diseases, Department of Laboratory Medicine ²Division of Neurological Diseases, Department of First Pathology, Wakayama Medical College キーワード： experimental atherosclerosis , calcium , aluminum , phosphorus Keyword: experimental atherosclerosis , calcium , aluminum , phosphorus pp.325-331

発行日 1990年4月1日 Published Date 1990/4/1

DOI https://doi.org/10.11477/mf.1406900038

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Abstract 文献概要
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　中枢神経組織（CNS）の変性にカルシウム（Ca），アルミニウム（Al），燐（P）が関与することが指摘されている。この研究はコレステロール誘発性粥状動脈硬化症家兎のCNS，肝，腎におけるCa, Al, Pの含有量を測定し，かつ，これらのエレメント低下目的で14—ethoxycarbonyl—（3α，16α—ethyl）−14,15—eburnamenine（vinpocetine）を投与したものである。16匹雄性家兎を次の4群に分け，（A）家兎標準食，（B）1.5％コレステロール添加標準食，（C）1.5％コレステロール添加標準食＋vinpocetine3mg／kg／day，（D）1.5％コレステロール添加標準食＋vinpocetine10mg／kg／dayを経口投与し3カ月間飼育した。（B），（C），（D）群では高脂血症とKritchevskyにより記載された粥状動脈硬化症が作成された。CNS，肝，腎のCa, P, Al含有量が放射化分析法で測定された。1）B群の各部位のCa含有量がA群のそれより増加し，CおよびD群のCa含有量はB群に比べ低下した。2）B群の前頭葉のP含有量はA群のそれより高値で，その他の部位では増加傾向を示した。C, D群はB群より低値を示した。3）A群に比べB群のAl含有量は高値で，またC群はB群より低下傾向を示し，D群は有意に低値を認めた。以上の結果から，Ca, P，Alと粥状動脈硬化症との関係が示唆されるとともに，vinpocetineによるそれらエレメントの低下作用を認めた。

The aims in this study were designed to clarify the contents of calcium (Ca), phosphorus (P) and aluminum (Al) in central nervous system (CNS), li-ver and kidney of rabbits with atherosclerosis ex-perimentally induced by cholesterol-rich diet, and investigate scavenger effect of 14-ethoxycarbonyl-(3a, 16 a-ethyl)-14, 15-eburnamenine (vinpocetine) on the deposition of these elements in CNS and soft tissues of experimental atherosclerosis. Sixteen male rabbits were divided into 4 groups. Each group was fed with standard diet (Group A), sta-ndard diet containing 1.5% cholesterol (Group B), standard diet containing 1.5% cholesterol plus oral administration of 3 mg/kg/day vinpocetine (GroupC), and standard diet containing 1.5% cholesterol plus administration of 10 mg/kg/day vinpocetine (Group D). After 3 months' feeding, experimental atherosclerosis was produced with a modified me-thod of Kritchevsky et al in rabbits of Groups B, C and D. Blood was collected by cardiocentesis un-der the anesthesia of ether and then rabbits sacri-ficed to remove CNS and other tissues. The blood was stood for 1 hour at room temperature and se-parated by centrifugation at 3000 rpm for 10 min to determine serum total cholesterol, phospholipids, HDL-cholesterol, peroxide lipid, NEFA and calci-um levels.

Ca, P and Al contents in the frontal lobe, pons, cerebellum, spinal cord, liver and kidney were de-termined by neutron activation analysis. Ca con-tents of CNS, liver and kidney in Group B signi-ficantly increased than those of Group A (p＜ O.01), and significantly decreased in Groups C and D co-mpared with those of Group B (p＜0.01). Ca con-tents of pons and spinal cord in Group C, and of pons in Group D were significantly lower than those of Group A (p＜0.05, p＜0.01). P contents in the frontal lobe of Group B were higher than those in Group A (p＜0.01). And also P contents of CNS, liver and kidney in Groups C and D sig-nificantly decreased as compared with those of Group B. Al contents of Group B were higher in frontal lobe, spinal cord and kidney of Group A (p＜0.05), and the contents of CNS, liver and kid-ney of Group D were significantly decreased than those of Group B.

These results lead to the conclusion that the lar-ge contents of Ca, P and Al in CNS, liver and kid-ney were deposited and the scavenger action of vinpocetine on deposition of elements in these tissues were demonstrated in rabbits with exper-imental atherosclerosis.