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POSITRON EMISSION TOMOGRAPHY (PET) STUDY IN PATIENTS WITH MENINGIOMAS Katsuyoshi Mineura 1 , Toshio Sasajima 1 , Masayoshi Kowada 1 , Fumio Shishido 2 , Kazuo Uemura 2 1Neurosurgical Service, Akita University Hospital 2Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita Keyword: meningioma , hemocirculation , metabolism , edema , positron emission tomography(PET) pp.145-151
Published Date 1990/2/1
DOI https://doi.org/10.11477/mf.1406900016
  • Abstract
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Regional hemocirculation and metabolism were evaluated in five patients with meningiomas using positron emission tomography (PET). Histological diagnoses were : two cases of meningotheliomatous type, one hemangiopericytic type, one fibroblastic type, and one transitional type. Regional cerebral blood flow (rCBF), blood volume (rCBV), oxygen extraction fraction (rOEF), and metabolic rates of oxygen (rCMRO2) and glucose (rCMRG1) were measured with 15O2, C15O.15O2, and 18F-fluoro- deoxyglucose tracers. For the quantitative analysis, regions of interest were delineated on tumors, the peritumoral region, and the contralateral graymatter in comparison with age-corresponding 5 malignant gliomas and 5 normal volunteers. Tu-mor hemocirculatory parameters (rCBF : 57.2±. 22.6 ml/100 ml/min, rCBV : 7.95± 3.27 ml/100 ml, mean + SD, n= 5) were markedly higher than those of the contralateral gray matter (p <O.05 by a Student-t test). The high values were consistent with angiographic findings of tumor staining and with abundant tumor vessels demonstrated by pathological examination. rCMRO2 was 2.15± 0.80 ml/100 ml/min, which were comparable to those of the contralateral gray matter. Tumor rCMRG1 showed 4.76±2.37 mg/100 ml/min ; the values of two cases were similar to the respective gray matter. The raised metabolic rate (rCMRO2/ rCMRG1) therefore suggests rather aerobic gly-colysis as compared with gliomas. Low rOEF (0.26± 0.16) reveals an excessive blood flow be-yond oxygen demand of the tumor. In the peri-tumoral regions, rCBF and metabolism fell slightly but rOEF reached a level similar to the contra-lateral gray matter, possibly due to hemocirculatory stasis caused by intracranial hypertension ; in contrast, an unmatched reduction of rCBF and rCMRO2 implies tumor cells infiltration in gliomas.

PET can provide us in vivo quantitative know-ledge of hemocirculatory and metabolic perturba-tion in patients with meningiomas.


Copyright © 1990, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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