Japanese

ISCHEMIC AXONAL INJURY AND ITS RECOVERY AFTER FOCAL CEREBRAL ISCHEMIA Junji Taguohi 1 , Kazuo Yamada 2,3 , Toru Hayakawa 2 , Kazuo Kataoka 2 , Eiji Komura 2 , Kazutami Nakao 2 , Katsumi Matsumoto 2 , Heitaro Mogami 2 , Nobuhiro Kanai 1 1Department of Neurosurgey, Toyonaka Municipal Hospital 2Department of Neurosurgery, Osaka University, Medical School pp.813-818
Published Date 1989/8/1
DOI https://doi.org/10.11477/mf.1406206373
  • Abstract
  • Look Inside

After focal cerebral infarction by occluding the middle cerebral artery (MCA) of the rat, the neu-ronal death occured in the ipsilateral thalamicneurons, because axons of the thalamic neurons were injured by infarction and retrograde dege-neration occured in the thalamic neurons. How-ever, cortical neurons adjacent to the infarction survived despite their axons injured by ischemia. We employed immunohistochemical staining for 200 kilodalton (kD) neurofilament (NF), in order to study those responses of cortical and thalamic neurons against axonal injury caused by focal cerebral infarction. In the sham operated rats the immunoreactivity to the anti-200 kD NF antibody was only detected in the axon but not in the cell bodies and dendrites. At 3 days after MCA occlu-sion, axonal swelling proximal to the site of ischemic injury was found in the caudoputamen and internal capsule of the ipsilateral side. At 7 days after occlusion, cell bodies and dendrites of the neurons in the ipsilateral cortex and thalamus were strongly stained with anti-NF antibodies. At 2 weeks after occlusion these responses disap-peared in the cortex, but lasted in the thalamus. These phenomena are caused by stasis of the slow axonal transport, because the NF is transported by slow axonal transport. In the cortical neurons impairment of slow axonal transport recovered in the early phase after injury, but in the thalamic neurons the impairment prolonged up to 3 weeks after occlusion. The early recovery of axonal transport from ischemia seemed to be essential for survival of neurons after ischemic axonal injury.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

関連文献

もっと見る

文献を共有