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LOCAL CEREBRAL BLOOD FLOW AND GLUCOSE METABOLISM IN EXPERIMENTAL MENINGEAL CARCINOMATOSIS Noriko Yamada 1 , Kazuo Yamada 1 , Yukitaka Ushio 1 , Toru Hayakawa 1 , Heitaro Mogami 1 1Department of Neurosurgery, Osaka University Medical School pp.1077-1085
Published Date 1986/11/1
DOI https://doi.org/10.11477/mf.1406205809
  • Abstract
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Patients with meningeal carcinomatosis often evolve signs of impairment in higher mental func-tion. Yet, common findings of histological obser-vation are only a sheet of tumor cells on the cortical surface, and no intracerebral mass are noted. To elucidate mechanism of mental disturb-ances in meningeal carcinomatosis, local cerebral blood flow and glucose metabolism were evaluated in a model of experimental meningeal carcinoma-tosis.

Viable cells (1×104) of Walker 256 tumor were inoculated into cisterna magna of Wistar rats. Animals were used for autoradiographic study at 1 to 12 days after tumor inoculation. Local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF) were measured with quantitative au-toradiographic technique using 14C-iodoantipyrine and 14C-deoxyglucose as a tracer, respectively.

In the early stage of tumor growth (1 to 3 days after tumor inoculation), reduction of LCGU was averaged to be 31% in the cerebral cortex and 28% in the deep structures, whereas reduction of LCBF was 28% in cerebral cortex and 19% in deep structures on average. In the late stageof tumor growth (4 to 12 days after tumor inocula-tion), average reduction of LCGU was 57% in the cerebral cortex and 47% in the deep struc-tures. On the other hand, reduction of LCBF was averaged to be 42% in the cerebral cortex and 38% in the deep structures in the late stage of the disease. Reduction of LCGU and LCBF was especially evident in the sensory cortices such as parietal cortex, visual cortex and auditory cortex, and in the auditory centers of the brain stem such as medial geniculate body and inferior colliculus. There was no definite evidence that blood flow and glucose metabolism of the cortex underneaththe sheet of tumors were suppressed by the tumor.

Coupled suppression of blood flow and glucose metabolism during the early stage of tumor growth was probably the result of diffuse cortical sup-pression due to mild hydrocephalus and increase in intracranial pressure. Suppression of glucose metabolism during the late stage was probably the result of suppression of sensory system due to tumor invasion to the cranial nerves and spinal roots, and the result of impairment in the ascend-ing reticular activating system by direct invasion of the tumor to the floor of the fourth ventricle.


Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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