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STUDIES ON ULTRASTRUCTURAL CHANGES IN PERIVASCULAR CELLS (F. G. P.) OF SMALL CEREBRAL VESSELS AT THE INITIAL STAGE AFTERCOLD INJURY:CHRONOLOGICAL OBSERVATIONS ON F. G. P. WITHIN 24 HOURS Shuichi Fukuda 1 , Masao Mato 1 1Department of Anatomy, Jichi Medical School pp.349-357
Published Date 1985/4/1
DOI https://doi.org/10.11477/mf.1406205494
  • Abstract
  • Look Inside

As the potentiated cells in reaction to cerebral edema and damage, microglia, astrocytes and mac-rophages had been listed. Recent neuropatholo-gical study elucidated that most of cerebral mac-rophages were derived from blood leucocytes including monocytes.

Several years ago, one of the authors reported the presence of histiocytic cells in peri vascular space and named them as fluorescent granular perithelial (F. G. P.) cells from their morphological characteristics.

The present paper is concerned with the res-ponse of the F. G. P. cells to the vasogenic edema induced with cold injury.

The animals employed were Wistar male rats aged 3 months. At 2, 6, 10, and 24 hours after the cold injury, cerebral cortex was excised, and spe-cimens were prepared for light and electron mic-roscopical observations.

As already reported, the F. G. P. cells included autofluorescent and PAS positive granules. The intracellular granules were rich in hydrolytic enzymes and lack in sudanophile substances. The F. G. P. cells were derived from leptomeningeal cells and acquired uptake capacity for exo- and endogenous substance after birth. In this paper, the F. G. P. cells locating in the boundary between cold injured and healthy regions were observed.

At 2 to 10 hours after cold injury, the F. G. P. cells were vacuolated and swollen, and the elect-ron opacity of them decreased moderately. Lipoid-al substance appeared in the intracellular granu-les first at 2 hours and then increased, while the activity of acid phosphatase in them became low in corresponding with a time interval after the cold injury. At this period, occasionally the F. G. P. cells possessed a complicated boundary to ast-rocytes surrounding them.

In general, such morphological changes were reversible and recovered partially around at 24 hours. Further, at this final stage, deep plasma-lemmal invaginations developed on the F. G. P. cells, and contacted firmly to projections of leu-cocytes.

The evidence mentioned above suggests the contribution of the F. G. P. cells for scavenging extracellular fluid in a cerebral edema. During the experiment, migration and proliferation of the F. G. P. could not be detected.


Copyright © 1985, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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