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CEREBRAL AMYLOID ANGIOPATHY IN ALZHEIMER'S DISEASE:WITH SPECIAL REFERENCE TO ITS INCIDENCE AND DISTRIBUTION Susumu Ando 1 , Hiroshi Nakayama 1 1National Musashi Research Institute for Mental and Nervous Diseases pp.1109-1116
Published Date 1984/11/1
DOI https://doi.org/10.11477/mf.1406205412
  • Abstract
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In 10 autopsied cases of terminal stage of Alz-heimer's disease, the incidence and distribution of amyloid angiopathy (AA) in the brain were mea-sured under light microscope. Further, the distri-bution and intensity of Alzheimer's neurofibrillary change (NFT), senile plaque (SP), and loss of neurons (CL) were compared among the indivi-dual cases.

1) NFT and SP were frequently seen over wideareas with little individual variations.

2) AA was present in all cases, but its distri-bution and frequency markedly differed from individual to individual. Generally, AA was rela-tively common in the pia and cortical upper layers of the frontal, temporal and occipital lobe, orbital gyrus and cerebellum, but there was no particular site showing very high rate of occurrence.

3) SP and NFT had no correlation to AA in regard to their site and frequency.

4) In all cases, the nucleus basalis of Meynert showed marked loss of neurons and very frequent occurrence of NFT.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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