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Japanese

HISTOPATHOLOGICAL STUDY ON EXPERINIMENTAL CEREBRAL INFARCTION IN RAT Hidemi Kishikawa 1 , Kazuo Tabuchi 1 , Takashi Ohmoto 1 , Akira Nishimoto 1 1Department of Neurological Surgery, Okayama University Medical School pp.555-560
Published Date 1979/6/1
DOI https://doi.org/10.11477/mf.1406204419
  • Abstract
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An experimental model of cerebral infarction in rat brain was successfully established by means of the unilateral internal carotid injection of carbon microspheres. A histopathological investigation of the infarcted brain was performed. The results were as follow;

1. No cerebral infarction was made by the uni-lateral internal carotid ligation alone.

2. Focal cerebral edema was most marked at the white matter of the embolized hemisphere.

3. The edema was also conspicuous in the deep cerebral gray matter, especially in hippocampus. Degeneration and pyknosis of the neurons were observed at the same area.

4. Transudative hemorrhage in the focal cerebral edema was usually observed in the thalamus.

5. Edematous change in the cortical gray matter was not so marked as compared with the hippo-campus and thalamus.

6. Carbon microsphere was not found in the capillaries of ipsilateral choroid plexus.

The present experimental model of cerebral infarction will be useful in elucidating the patho-logical mechanisms of the cerebral infarction.


Copyright © 1979, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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