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INFUNDIBULO-PITUICYTOMA AND GRANULAR-CELL MYOBLASTOMA:Report of cases & review of the literature Hiroaki SEKINO 1 , Masakatsu, NAGAI 1 , Hiroo CHIGASAKI 1 , Keiji SANO 1 1Dept. of Neurosurg., Univ. of Tokyo, Faculty of Medicine pp.911-920
Published Date 1969/8/1
DOI https://doi.org/10.11477/mf.1406202586
  • Abstract
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Three cases of the infundilmlo-pituicytoma and one case of the so-called granular-cell myoblastoma were reported. The clinical data of them were indi-cated in Tab. 2. the histological characteristics of three cases (No. 1-3) were pilocytic astrocytes, vascular channel or lake and eosinophilic colloidal droplets. The histological findings of case 4 was very similar to those of the granular-cell myoblastoma of the neurohypophysis described by Harland in 1953.

In 1942,Globus first reported the neurohypophyseal tumor and gave it the name INFUNDIBULOMA, due to similarity between the neoplastic elements and the normal infundibulum, especially in its vascu-lra pattern ; the hypophyseal portal-veins.Liss and Kahn, in 1958, studied the pituicytes and propounded that INFUNDIBULOMA, described by Globus and GRANULAR-CELL MYOBLASTOMA, described by Harland, should he classified as the same category ; PITUICYTOMA.

In the literature, 14 cases of infundibulo-pitui-cytoma, including our three cases and 13 cases of granular-cell myoblastoma, including one case of ours, have been reported. Age distribution and sex difference of these two groups were illustrated in Fig. 4. It showed that the group of infundibulo-pituicytoma prevailed in males (M : F 10 : 4) and children (average age : 14 years), while the group of granular-cell myoblastoma appeared mainly in females (M : F 3 : 10) and adults (average age : 40 years). In the group of infundibulo-pituicytoma, 12 out of 14 cases steered a fatal course within several years from the onset of the illness. The characta-ristic symptoms and signs of this group were intra-cranial hypertension (11/14), visual disturbances (8/8) and psychic disorders (9/14). Hormonal disturbances were rare. In the group of granular-cell myoblas-toma, visual disturbances were the main symptoms and signs (10/12) and intracranial hypertension ap-peared less frequently than in the group of in-fundibulo-pituicytoma.

On the basis of these clinical findings, we are of the opinion that INFUNDIBULO-PITUICYTOMA and GRANURAL-CELL MYOBLASTOMA should belong to the different clinico-pathological entities.


Copyright © 1969, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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