統合失調症急性期入院患者の好中球/リンパ球比と血清蛋白量の前向き研究—経時的変化，精神症状との関連，数量的診断について

A Prospective Study of Neutrophil/Lymphocyte Ratio and Serum Protein Levels in Acute Hospitalized Patients with Schizophrenia : Temporal Changes, Relationships with Psychiatric Symptoms, and Quantitative Diagnosis

抄録

　当院の急性期病棟に新たに入院した統合失調症の患者のうち，研究に同意した51人（男26人，女25人）に対して，入院時から4週間ごとに，白血球分画，血清蛋白の検査と簡易精神症状評価尺度（BPRS）による精神症状評価を行った。統合失調症群の好中球/リンパ球比（NLR）は，入院時に対照群と比較して有意に高かったが，4週間以降は正常化した。血清総蛋白は，対照群と比較して入院時に低下しており，12週間まで低下が継続した。NLRは，精神症状との関連がみられたが，血清総蛋白は，精神症状との関連がみられなかった。NLR，総蛋白，性別，年齢を用いて判別分析を行い，統合失調症の数量的診断を試みた。その結果，中等度の精度で診断予測が可能であると考えられた。

　Fifty-one patients with schizophrenia（26 males and 25 females）who agreed to the study were examined for leukocyte fractionation and serum protein and psychiatric symptoms assessed by BPRS every four weeks from the time of admission. The neutrophil/lymphocyte ratio（NLR）in the schizophrenia group was significantly higher than in the control group at admission, but normalized after 4 weeks. Serum total protein was lower at admission than in the control group and continued to decline until week 12. NLR was associated with psychiatric symptoms, but serum total protein was not associated with psychiatric symptoms. Discriminant analysis using NLR, total protein, sex, and age was performed to quantitatively diagnose schizophrenia. As a result, it was possible to predict the diagnosis with moderate accuracy.