Japanese

A Retrospective Study on the Utility of Fluvoxamine, Milnacipran and Paroxetine for Treating Bipolar Depression Yuji KITAICHI 1 , Takeshi INOUE 1 , Katsuji SUZUKI 2 , Teruaki TANAKA 1 , Minoru HONDA 3 , Shin NAKAGAWA 1 , Ichiro KUSUMI 1 , Tsukasa KOYAMA 4 1Department of Psychiatry, Hokkaido Graduate School of Medicine, Sapporo, Japan 2Department of Mental Health, Aomori Prefectural Central Hospital 3Honda Memorial Hospital 4Ohyachi Hospital Keyword: Bipolar depression , Fluvoxamine , Milnacipran , Lithium carbonete pp.293-299
Published Date 2015/4/15
DOI https://doi.org/10.11477/mf.1405204895
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 A naturalistic, retrospective study was conducted to the assess antidepressant effects of fluvoxamine and milnacipran (as compared with paroxetine) as well as their effects on maniac switch or mood lability for treating bipolar depression. No differences were observed in antidepressant effects and maniac switch or mood lability between antidepressants or bipolar subtype diagnosis. Antidepressants, together with lithium carbonate, significantly decreased “maniac switch or mood lability” The highest dose of fluvoxamine and milnacipran in the “mildly effective or no effective” groups were significantly higher than those in the “remission or recovery” groups. These results suggest that the antidepressant effects of fluvoxamine and milnacipran and their effects on maniac switch of mood lability in treatment of bipolar depression are generally equivalent to those of paroxetine. Furthermore, lithium carbonate is beneficial for decreasing maniac switch of mood lability via SSRIs/SNRIs.


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電子版ISSN 1882-126X 印刷版ISSN 0488-1281 医学書院

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