Thiepin系抗精神病剤Zotepineの作用の新しい側面—鎮静・抗躁効果と血清尿酸値低下作用について

New Aspect of Effect of Thiepin Derivate, Zotepine: The correlation between sedativeantimanic effect and reducing effect on level of serum uric acid

　抄録　Thiepin系Zotepineは，すでにこれまで一定の抗精神薬作用があることが認められすでに市販されている。

　筆者らの研究によれば，Zotepineの標的症状として，まず，興奮があげられる。その興奮が，緊張病性，反応性，躁性の区別なく，それらに対する鎮静作用の強いことが明らかにされた。次いで，抗異常体験作用，若干の情意鈍麻改善作用も認められた。副作用として，眠気，全身倦怠感，運動遅鈍が強く，錐体外路症状は少なくて弱い。口渇，便秘など抗コリン性副作用も少ない。

　Thiepine derivate, Zotepine, has already been known to have a neuroleptic effect and is broadly on the market in Japan. The result of our clinical study on Zotepine shows that its main target symptom is excitement. No matter how catatonic, reactive or manic the nature of excitement may be, this drug has a strong sedative effect on it. We found, secondarily, antihallucinatory-delusional effect and some effect on emotional disturbance. As far as side effects are concerned, drowsiness, fatigue, and motorretardation are prominent, however parkinson's symptom and anticholinergic symptom are less and weak.

　In addition, this drug considerably reduces the level of serum uric acid and this function is, we infer, mutually related to sedative-antimanic effect. No other psychotropic drug has been reported to effect metabolism of uric acid so far, thus this drug has quite a new and unique role.