Four Depressive Patients in whom Migraine was Improved by Paroxetine Administration Sayaka KIDA 1,2 , Hajime BABA 1 , Toshihito SUZUKI 1 , Heii ARAI 1 1Department of Psychiatry, Juntendo Koshigaya Hospital, Koshigaya, Japan 2Department of Psychiatry, Juntendo University School of Medicine Keyword: Migraine , Depression , Paroxetine , Serotonin , SSRI pp.1079-1086
Published Date 2008/11/15
DOI https://doi.org/10.11477/mf.1405101315
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 We report on 4 cases of depressive patients in whom migraine was improved by paroxetine administration. Antidepressants such as SSRIs are known to alleviate migraine symptoms. Two distinct pharmacological mechanisms underlie the clinical effects obtained. These mechanisms mediate a secondary effect by improving depressive symptoms, which could be a precipitating factor for pain, and a direct action on the development of migraine through serotonergic neural systems. Interestingly, our patients showed an early improvement of migrain on treatment with paroxetine before showing an improvement depressive symptoms. This suggests that paroxetine may improve migraine through incite a direct serotonergic action in the central nerve system (CNS), rather than through the improvement of depressive symptoms.

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