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Clinical Effects of High Oral Dose of Donepezil in Patients with Alzheimer's Disease Motohiro NOZAWA 1 , Yosuke ICHIMIYA 1 , Hideki SUGIYAMA 1 , Eiko NOZAWA 2 , Ryo HANZAWA 1 , Yushi UTSUMI 1 , Ryoko YAMAMOTO 1 , Norio MURAYAMA 1 , Ryo KUMAGAI 1 , Eizo ISEKI 1 , Heii ARAI 2 1Department of Psychiatry, Juntendo Tokyo Koto Geriatric Medial Center, Juntendo University School of Medicine, Tokyo, Japan 2Department of Psychiatry, Juntendo University School of Medicine Keyword: Donepezil , Alzheimer's disease , Dementia , High oral dose , Apolipoprotein E4 pp.975-980
Published Date 2008/10/15
DOI https://doi.org/10.11477/mf.1405101292
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 A daily dose of 10mg donepezil for severe Alzheimer's disease (AD) patients was licensed in Japan since the end of August 2007;but most Japanese patients with AD are prescribed a daily dose of 5mg donepezil for more than 4 weeks. In addition, it has been confirmed in foreign countries that a daily dose of 10mg of donepezil is effective for mild-to-moderate AD patients. We initiated medical treatment in 57 AD patients at a daily dose of 10mg donepezil and subsequently assessed examined the clinical effects, adverse effects, and the relation with apolipoprotein E4 in these patients. We observed that a daily dose of 10mg donepezil could stabilize or slow down the progression of cognitive impairment in our patients. The severity of AD, the duration of medication with 5mg donepezil and the apolipoprotein E genotype did not influence any clinical effects. The incidence of adverse effects in this study was 12.3%, which was considerably lower than the incidence rate of 40% in the previous clinical trial in Japan. These findings suggest that long-term medication with a daily dose of 5mg donepezil might be associated with fewer adverse effects.


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電子版ISSN 1882-126X 印刷版ISSN 0488-1281 医学書院

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