雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Spontaneous Ecchymoses Developed on a Patient under Medication of Paroxetine for Panic Disorder, Even though Her Platelet Count and Bleeding Time were Normal Sumihiro NAKASHIMA 1 1National Hospital Organization, Shimofusa Medical Center of Psychiatry Keyword: Ecchymoses , Paroxetine , Panic disorder , ADP , Platelet pp.425-429
Published Date 2006/4/15
DOI https://doi.org/10.11477/mf.1405100250
  • Abstract
  • Look Inside
  • Reference
  • Cited by

Summary

 A 30-year-old woman diagnosed as panic disorder and who was under medication of paroxetine 30mg/day developed ecchymoses on her four extremities, but the investigations showed that her platelet-count and bleeding time were normal. By decreasing the dose of paroxetine her ecchymoses gradually diminished, but withdrawal symptoms, headache and hypersensitivity developed, which made it difficult to deal with the bleeding event. This is the first Japanese case report of bleeding with normal platelet count and normal bleeding time under medication of paroxetine. The patient had not noticed the event was due to paroxetine and continued to take it as had other patients described in some of the reports on this phenomenon. Practitioners should give an explanation of the bleeding side-effect of this selective serotonin reuptake inhibitor (SSRI) to patients for whom they prescribe paroxetine. Withdrawal symptoms of SSRI make it difficult to deal with the bleeding. The process of the bleeding events caused by SSRIs may be related to the fact that they inhibit ADP-induced platelet aggregation, and/or to capillary fragility.


Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-126X 印刷版ISSN 0488-1281 医学書院

関連文献

もっと見る

文献を共有