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The Administration of a Phosphodiesterase Inhibitor and a Calcium Sensitizer for Severe Congestive Heart Failure Caused by Therapy for Leukemia: an evaluation using stress-velocity relationship Tomoaki Murakami 1 , Yasuhisa Odagawa 1 , Ryoji Kobayashi 1 , Satoshi Shida 1 , Kyosuke Hazama 1 , Kiyoshi Nagumo 1 , Makoto Yoshida 1 , Akihiro Iguchi 1 , Naoki Watanabe 1 , Kunihiko Kobayashi 1 1Department of Pediatrics, Hokkaido University School of Medicine Keyword: 心不全 , ホスホジエステラーゼ阻害剤 , カルシウム感受性増強剤 , heart failure , phosphodiesterase inhibitor , calcium sensitizer pp.305-308
Published Date 2000/3/15
DOI https://doi.org/10.11477/mf.1404902064
  • Abstract
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 We report a case of a 16-year-old girl who wasadministered a phosphodiesterase inhibitor, olprinonehydrochloride, and a calcium sensitizer, pimobendan, forthe treatment of severe congestive heart failure possibledue to leukemia therapy. The olprinone hydrochloridedecreased the afterload, so that the left ventricularpump function improved, but left ventricularcontractility did not change. The pimobendan improvedthe left ventricular pump function through decrease ofthe afterload and increase of the contractility of the leftventricle. These drugs may be effective for the management of congestive heart failure caused by therapy forleukemia.


Copyright © 2000, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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