Estimation of Pulmonary Arterial Compliance in Chronic Obstructive Pulmonary Disease Hitomi Yokoyama 1 , Toshiyuki Sawa 2 , Tsutomu Yoshida 2 , Hiroyasu Ito 1 , Shinya Minatoguchi 3 , Norio Yasuda 3 , Yasushi Ohno 3 , Koji Goto 3 , Hisayoshi Fujiwara 3 1Sawada Hospital 2Gifu Municipal Hospital 3Second Department of Internal Medicine, Gifu University Keyword: 慢性閉塞性肺疾患 , 肺動脈コンプライアンス , 血漿ノルアドレナリン濃度 , chronic obstructive pulmonary disease , pulmonary arterial compliance , plasma noradrenaline concentration pp.1037-1041
Published Date 1999/10/15
DOI https://doi.org/10.11477/mf.1404901982
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In 26 patients with chronic obstructive pulmonary disease (COPD), mean pulmonary arterial pressure (mPA) and pulmonary vascular resistance index (PVRI) were measured at rest and during oxygen inha-lation by right cardiac catheterization. Plasma nora-drenaline (NA) concentration was measured simultane-ously. Pulmonary arterial compliance (Cp) was esti-mated from the pulmonary arterial pressure curve by Levenson' s method. 26 patients were divided into two groups; Group L (%FEV1.0≦55, n=12) and Group H (55<%1.0≦70, n=14). Plasma NA level in group L was higher than that in group H (p<0.05) at rest and decreased during oxygen inhalation significantly (p< 0.05). While no significant difference was seen in mPA, PVRI and Cp at rest in both groups, mPA in both groups decreased (p<0.01) and Cp in group H increased significantly (p<0.01) during oxygen inhalation.

It is concluded that oxygen inhalation improves Cp in mild COPD, but not in severe COPD, in spite of the fact that it decreases both NA and mPA in severe COPD. These results suggest that remodeling of pulmonary vascular structure is the cause of failure in improvement of Cp in severe COPD.

Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.


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