A Case of Alcohol-induced Variant Angina Associated with High Level of Plasma Endothelin-1 Bunji Kaku 1 , Sumio Mizuno 1 , Kazuo Ohsato 1 , Tatsuaki Murakami 1 , Ikuo Moriuchi 1 , Yoshiyuki Arai 1 , Yutaka Nio 1 , Koutaro Ooe 1 , Tomohito Mabuchi 1 , Yoshifumi Takahashi 1 1Fukui Cardiovascular Center Keyword: アルコール , 異型狭心症 , エンドセリン−1 , alcohol , variant allgilla , endothelin-1 pp.191-195
Published Date 1999/2/15
DOI https://doi.org/10.11477/mf.1404901851
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A 70-year-old man was admitted to our hospital because of chest pain which occurred several hours after alcohol ingestion. In an attempt to provoke the attack by alcohol ingestion, we gave the patient alcoholicbeverage (sake containing 15% alcohol, 360 ml) at the hospital (alcohol test). Alcohol-induced variant angina was provoked 4.5 hours after alcohol ingestion and ST elevation was seen in II, III, aVF leads. The alcohol test was repeated during cardiac catheterization. Coronary angiography showed no organic stenoses in either coronary artery. Although variant angina did not occur spontaneously during cardiac catheterization, spasticity of the right coronary artery increased 5 hours after alcohol ingestion.

Later, subtotal spasm of the right coronary artery was induced by intracoronary injection of acetylcholine (15 μg). Plasma ethanol level had already returned to nillevel at this time.

We also measured the endothelin-1 level in the peripheral vein. The endothelin-1 level was 3.15 pg/ml with-out drinking and it increased to 4.09 pg/ml during alcohol test (normal range ; less than 2.30 pg/ml). Two months after abstaining from drinking, it decreased to 2.88 pg/ml.

Although this report is a case report of only one patient, there may be some relationship between alcohol-induced variant angina and plasma endothelin-1 level.

Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.


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