Kokyu to Junkan Volume 45, Issue 10 (October 1997)

Two Cases of Hypopituitarism with Electrocardiographic Abnormalities Tetsu Kobayashi 1 , Uichirou Shintani 2 , Osamu Taguchi 1 , Yukihiko Adachi 2 13 rd Department of Internal Medicine, Mie University School of Medicine 2Department of Internal Medicine, Tsu National Hospital Keyword: 汎下垂体機能低下症 , ACTH単独欠損症 , 心電図異常 , panhypopituitarism , isolated adenocorticotropin deficiency , electrocardiographic abnormarity pp.1027-1031
Published Date 1997/10/15
DOI https://doi.org/10.11477/mf.1404901576
  • Abstract
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The first case was a man of 84 years of age, with a past history of fainting associated with a prolonged QT interval and non-sustained VT on the electrocardio-gram (ECG). He was suspected of suffering from adrenocotical hypofunction. His symptom improved after treatment with prednisolone. During his clinical follow-up, he suffererd from a similar crisis after with-drawal of prednisolone and was again hospitelized. After various loading tests, isolated adrenocorticotropin deficiency was revealed. Therapy with cortisol im-proved his electrocardiographic abnormalities. The sec-ond case was a 59-year-old man who was admitted for disturbance of consciousness, and loss of pubic and axillary hair. Panhypopituitarism was diagnosed based on the results of various loading tests, the MRI findings being compatible with the diagnosis of empty sella. On admission. the ECG showed a prolonged QT interval, sinusal bradycardia and negative T wave. Theseelectrocardiographic abnormalities improved after administration of hydrocortisol and thyroid hormones. Reports on the association between hypopituitarism and electrocardiographic abnormalities are uncommon. Endocrinological diseases must also be taken into con-sideration as a potential causative factor of electrocar-diographic abnormalities.

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45巻10号 (1997年10月)
電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院