Effect of Postprandial Administration of Propafenone on Diurnal Variation of Premature Ventricular Contractions Masashi Horimoto 1 , Masafumi Fujiwara 1 , Ken-ichi Koguchi 2 , Keiichi Igarashi 2 , Takashi Takenaka 2 1Division of Cardiology, Sapporo National Hospital 2Division of Internal Medicine, Ishikari Hospital Keyword: プロパフェノン , 食後投与 , 心室性期外収縮 , 口内変動 , propafenone , postprandial administration , premature ventricular contractions , diurnal variation pp.55-60
Published Date 1995/1/15
DOI https://doi.org/10.11477/mf.1404900988
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Diurnal variation of premature ventricular contrac-tions (PVCs) and the effect on the variation of post-prandial administration of propafenone (PF) was stud-ied in 22 patients with PVCs > 3000/day. PF was administered with 150mg three times a day. Ambu-latory 24-hour Holter monitoring was performed beforeand after the administration of PF.

Daily total PVCs were reduced by 75.2±5.9% (mean±SE) after the administration of PF. Three types of diurnal variation of PVCs, daytime, nocturnal and all-day patterns, were demonstrated before the drug was administered. Postprandial administration of PF abolished the diurnal variation of PVCs in the daytime and in the nocturnal patterns. The ratios of the daytime frequency of PVCs at the postmedication period to premedication period were 28.5% in the day-time pattern, 19.5% in the nocturnal pattern and 8.9% in the all-day pattern. Whereas, the ratios of the noctur-nal frequency of PVCs at the postmedication period to premedication period were 77.0% in the daytime pat-tern, 13.6% in the nocturnal pattern and 40.9% in the all -day patter. No significant differences were noted between the percent ratios in the day-time and at night.

This data indicate that the postprandial administra-tion of PF favorably suppressed PVCs at night as well as in the daytime despite the relatively short elimina-tion half-life of PF. According to the literature, percent reduction of PVCs after 8-hourly administration of PF was 82.0 or 87.2%. This value is higher than the percent reduction obtained by postprandial administration of PF. Thus the previous suggestion is unlikely to be supported that the bioavailability of PF is increased with its postprandial administration.

Copyright © 1995, Igaku-Shoin Ltd. All rights reserved.


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