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Effects of Dobutamine and Isoproterenol on Systemic Hemodynamics and Myocardial Metabolism in Children after Open Heart Surgery Yoshiyuki Sakata 1 , Tetsuo Anzai 1 , Tetsuo Iijima 1 , Ichiro Yoshida 1 , Yoshiro Hamada 1 , Tamiyuki Obayashi 1 , Susumu Ishikawa 1 , Hajime Yanagisawa 1 , Hitoshi Kodama 1 , Akio Otaki 1 1The Second Department of Surgery, Gunma University School of Medicine Keyword: ドブタミン , イソプロテレノール , 心筋代謝 pp.65-70
Published Date 1992/1/15
DOI https://doi.org/10.11477/mf.1404900411
  • Abstract
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The purpose of this study is to know the effects of Dobutamine (DOB) and Isoproterenol (ISP) on thesystemic hemodynamics and myocardial metabolism in the acute phase after open heart surgery in children. Twelve patients with congenital heart disease were administered 5 and 10 pg/kg/min (γ) of DOB, then 0.005 and 0.01 γ of ISP, and the systemic hemodynamic and metabolic data were taken before and after the administration of the drugs.

DOB : DOB increased HR and SVI, so CI rose up markedly. The systolic, diastolic and mean blood pres-sure also rose up after both doses. CVP and PCWP were depressed at both dosage levels.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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