冠動脈硬化と血清アポ蛋白およびリポ蛋白の関連について

Relation of serum apolipoprotein and lipoprotein and coronary atherosclerosis

　高脂血症が冠動脈硬化の発症進展に対する主要な危険因子の1つであることは，今日広く認められている。近年，血清リポ蛋白を構成するアポ蛋白の測定が容易になり，これらアポ蛋白と冠動脈硬化との関連が注目されている。本研究では，冠動脈造影よりみた冠動脈硬化の程度と血清脂質，リパ蛋白およびアポ蛋白との関係につき検討した。

The relationship of coronary artery disease (CAD) to with plasma lipids, lipoproteins and apolipoproteins was studied in 91 men who underwent coronary angio-graphy. In univariate analyses, the severity of CAD correlated significantly and positively with LDL and apo B/apo A-I, and negatively with apo A-I and HDL-C/TC. When multivariate regression analysis was used, apo A-I and LDL retained their significant association with coronary heart disease. It is concluded that both apo A-I and LDL are strongly and independently associated with the prevalence of coronary heart disease, whereas the level of HDL-C makes no statistically signi-ficant independent contribution.