笑気麻酔中の過換気効果とハロセンの影響

The Effects of Hyperventilation during Nitrous Oxide-Oxygen Anesthesia with and without Halothane on Human Cerebral Metabolism

　麻酔中には低換気による呼吸性アシドージスや低酸素血症を防ぐためにも過換気を行なうことが多い。

　笑気麻酔中筋弛緩剤を併用して過換気を行なうと麻酔効果が強められることは臨床麻酔上経験するところであり，過換気の併用により麻酔剤や筋弛緩剤の使用量を少なくすることができるといわれている^1）。

Deliberate hyperventilation is commonly ap-plied during anesthesia in the hope of poten-tiating the action of anesthetic agents. This study was to examine the effects of hyper-ventilation during nitrous oxide-oxygen anesthesia with and without halothane on human cerebralmetabolism by chemically analyzing the cerebro-spinal fluid (CSF). The first experiment cor-related the lactate, pyruvate, and Po₂, in CSF with the somatosensory evoked responses (EVR) on EEG. In addition, a comparison of cerebral oxygenation and metabolism was made between N₂O-O₂ anesthesia and N₂O-O₂-halothane anes-thesia.