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Alveolar Arterial Gas Tension Difference under Abnormal Conditions (2) Hirohisa Ohtsuka 1 1Department of Internal Medicine, School of Medicine, Keio University pp.275-280
Published Date 1970/3/15
DOI https://doi.org/10.11477/mf.1404202132
  • Abstract
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The effect of shift of oxygen dissociation curve upon alveolar arterial oxygen tension difference was studied under 4 different ab-normal conditions.

1. Anemia; Alveolar arterial oxygen tension difference on dogs with induced anemia was measured. Alveolar arterial oxygen tension difference was 10.3±1.3 mmHg when breath-ing 21 percent oxygen while that was 19.6 ± 3.8 mmHg when breathing 39.1 percent oxy-gen. This data was considered to remain within normal range.

2. Carbon monoxide inhalation; Alveolar ar-terial oxygen and nitrogen tension differences were measured when the anesthetized dogs breathed 21 percent oxygen and gas mixture containing 0.07 percent carbon monoxide and 19.5 percent oxygen. Statistical differencewas not significant between the alveolar arte-rial nitrogen tension difference prior to and after carbon monoxide inhalation. Alveolar arterial oxygen tension difference was signi-ficantly increased after carbon monoxide inha-lation.

3. Alkaline and acid infusion; To change blood hydrogen ion concentration, 0.3N NaOH or 0.3 N HCl were injected intravenously. Statistical differences were not found on the alveolar arterial nitrogen tension difference prior to and after the maneuver. Alveolar arterial oxygen tension difference prior to and after acid infusion was also not found. Alveo-lar arterial oxygen tension difference was sig-nificantly increased after alkaline infusion.

4. Conclusion; Leftward shifting of oxygen dissociation curve caused an significant incr-ease in the alveolar arterial oxygen tension difference.


Copyright © 1970, Igaku-Shoin Ltd. All rights reserved.

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