習慣的喫煙，飲酒歴のない食道表在癌の臨床病理学的特徴—第81回食道色素研究会における多施設共同研究

Clinicopathological Features of Superficial Esophageal Squamous Cell Carcinoma in Patients with No History of Smoking and Alcohol Consumption

要旨●第81回食道色素研究会において全国13施設から提示された習慣的喫煙，飲酒歴のない食道表在癌104例110病変と，横浜市立大学附属市民総合医療センターの習慣的喫煙・飲酒歴のある食道表在癌544例767病変を対象として，習慣的喫煙，飲酒歴のない食道表在癌の臨床病理学的特徴を明らかにした．それらの特徴は，①女性に多く，②重複がんは少なく，③多発ヨード不染帯は少なく，④GERDを伴うことが多く，⑤胸部中部食道（Mt）後壁の局在が多く，⑥0-IIa型が多く，⑦病理組織学的に上皮内癌成分が“表層分化型”である病変が多い，ことであった．

　The main risk factors for ESCC（esophageal squamous cell carcinoma）are cigarette smoking and alcohol consumption. However, a minority of patients had no history of exposure to these risk factors ; thereby, the etiology remains unknown in these patients. The clinicopathological features of superficial ESCC in never smokers and never drinkers were investigated. The cases were collected and discussed at the 81st Congress of the Japanese Research Society for Early Esophageal Cancer and Chromoendoscopy. One hundred and ten superficial ESCCs in 104 never smoker-never drinkers and 767 superficial ESCCs in 544 patients with a history of smoking and alcohol consumption were retrospectively investigated to show characteristic clinicopathological features such as female gender, absence of synchronous/metachronous cancer, grade A Lugol-voiding lesion, presence of gastroesophageal reflux disease, tumor location at the middle thoracic/posterior wall, type 0-IIa macroscopic type, and squamous cell carcinoma in situ with frequent clear zonal squamous differentiation.