Stomach and Intestine(Tokyo) Volume 54, Issue 13 (December 2019)
Japanese

Gastrointestinal Toxicity of Immune Checkpoint Inhibitor Kazunori Nagashima 1,2 , Takehiko Katsurada 3 , Takuya Otsuka 4 , Mutsumi Nishida 5,6 , Satomi Omotehara 5,6 , Kensuke Sakurai 1 , Shinsuke Otagiri 1 , Kana Yamanashi 1 , Yoshito Komatsu 7 , Tomoko Mitsuhashi 4 , Naoya Sakamoto 1 1Department of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Japan 2Department of Gastroenterology and Hepatology, Hokkaido Medical Center, Sapporo, Japan 3Department of Endoscopy, Hokkaido University Hospital, Sapporo, Japan 4Department of Pathology, Hokkaido University Hospital, Sapporo, Japan 5Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan 6Division of Diagnostic Center for Sonography, Hokkaido University Hospital, Sapporo, Japan 7Department of Cancer Chemotherapy, Hokkaido University Hospital, Sapporo, Japan Keyword: 免疫チェックポイント阻害薬 , 大腸炎 , 薬剤性大腸炎 , 悪性腫瘍 pp.1723-1732
Published Date 2019/12/25
DOI https://doi.org/10.11477/mf.1403201905
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 Immune checkpoint inhibitors are novel anti-cancer drugs with mechanisms that are different from conventional anti-cancer drugs. Unfortunately, they are associated with characteristic adverse events, termed irAE(immune-related adverse events), including colitis, pneumonitis, skin rash, interstitial nephritis, and thyroiditis. Colonoscopy is useful for the diagnosis of colitis, which presents with symptoms such as diarrhea, abdominal pain, and bloody stool, and it requires the exclusion of other diseases with similar symptoms. Guidelines recommend steroid therapy for grade ≧2 colitis according to the Common Terminology Criteria for Adverse Events. Furthermore, infliximab therapy is recommended for steroid-resistant colitis. Collaboration among oncologists, gastroenterologists, and other clinicians and medical staff is important for proper management of irAE in patients treated with immune checkpoint inhibitors.


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基本情報

05362180.54.13.jpg
胃と腸
54巻13号 (2019年12月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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