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要旨●白色不透明物質(WOS)は,NBI併用拡大内視鏡で明瞭に視覚化される粘膜表層の白色物質である.慢性胃炎粘膜の腸上皮化生,胃の上皮性腫瘍にしばしば認められる.WOSの正体は,上皮内,上皮下に集積した微小な脂肪滴であり,内視鏡からの投射光が強く散乱または反射されるために白色として認識される.WOSがあると上皮下の微小血管まで投射光が到達しないため,血管の視認性が低下する.WOSの形態学的特徴の違い(regular/irregular)は,癌と腺腫の鑑別に有用な指標となる.
WOS(white opaque substance)is a novel endoscopic finding that is frequently found in the intestinal metaplasia of chronic gastritis mucosa or gastric neoplasms. WOS is an accumulation of lipid droplets within the epithelium and subepithelium ; it appears white because the light projected by the endoscope is intensely scattered or reflected on the surface. The visibility of the blood vessel is low because the projected light does not reach the microvessel under the epithelium. The morphology of the WOS is a useful marker for differentiating whether the lesion is cancer or non-cancer.
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